Activation of Diazo Compounds by Fluorinated Triarylborane Catalysts

The diverse applicability of diazo compounds as versatile reagents has enlarged the chemical toolbox in organic synthesis. Over past few decades, transition metal-catalyzed compound activation ignited classical synthetic methodology via utilizing highly reactive metal carbenoid species. Many reviews have also appeared literature which discloses advantage and disadvantages compound. Recently, tris(pentafluorophenyl) borane-mediated reactions reconciled this research area due to potential for mild, environmentally-friendly, metal-free, non-toxic reaction conditions, reactivity patterns boranes towards compounds. In review, we discussed boron-diazo precursor adduct with using catalytic stoichiometric halogenated triarylboranes and, mechanism N2 release from reagent. This generates carbene species a key intermediate can further be exploited O−H, N−H, S‒H, C−H insertions, azide insertion, carbonate transfer, C‒C C=C bond forming reactions, [2+2] or [2+4] cascade cyclization annulation etc. review is classified by following themes: 1. Introduction 2. Diazo Activation Using Stoichiometric Boranes 3. Catalytic B(C6F5)3 4. Catalyzed Reactions 5. Conclusions